Ma-ergic regulation of compensative processes in the visual system of the brain

Abstract

Aim. A comparative analysis of the participation of neuromodulatory centers in the regulation of compensatory processes on the model of experimental retinal dystrophy. It is shown that the formation of the pathology is accompanied by the restructuring of the coherent relations of the EEG and the concentration of biogenic mo-neminov in the Central structures of the visual analyzer. Unlike Locus coeruleus, stimulation on the background of pathology n. Rapher restores the original distribution pattern of the links.The conclusion is made about the important role of serotonin in the activation of endogenous compensatory processes.

Materials and methods:  Experiments were conducted on 14 rabbits weighing 2.5-3.0 kg. EEG was recorded using macroelectrodes previously implanted under nembutal anesthesia (35 mg / kg) at the coordinates of the stereotactic atlas. The potentials of the primary visual cortex, the superior tubercles of the quadrupole, and the external cranial body were analyzed before and after the formation of experimental retinal dystrophy .

Results: Further analyzes showed that electrical stimulation against the background of dystrophy of the neuromodulatory centers nR and LC leads to a significant increase in the content of 5-HT and HA, respectively, both in the cortex and subcortical structures.

Conclusions: When analyzing the parameters of synchronization of cortical potentials in the process of developing a conditioned reflex, the dominance of low-frequency EEG rhythms and an increase in their coherence were revealed, which unequivocally testified to the activation character of the spatial EEG synchronization phenomenon. In special studies, an increase in the excitability of the cortical and subcortical structures of the brain was demonstrated at a higher level of synchronization and its decrease at a lower level. Experimental facts of this kind make a valid conclusion, according to which the extreme values ​​of the potential synchronization level reflect various functional states of the central nervous system.