Potential connection with panthdary cancer stem cells and retinoids
Abstract
Pancreatic cancer is still one of the biggest problems facing medical science. Late diagnosis, advanced stages of detection, lack of specific markers and resistance to chemotherapy make pancreatic cancer one of the most lethal types of cancer. Due to the failure of standard therapy, the 5-year survival rate for this disease is up to 10 percent. The main goal of modern research is to solve the problem of high resistance to standard therapy. It has been proven that cancer stem cells play an important role in resistance to chemotherapy in a number of cancers, especially in pancreatic cancer. It is suggested that the main target in the treatment of cancer should be cancer stem cells. Thus, only normal cancer cells die after standard therapy. Inactive cancer stem cells can survive and cause new cells to develop. Studies have shown that retinoids have a therapeutic effect against various types of cancer (including pancreatic cancer). Studies have shown that retinoic acid reduces stem cell properties in pancreatic cancer stem cells. Also, the effect of retinoic acid on markers of pancreatic cancer stem cells (CD24, CD44, CD133, ALDH1) was studied and it was found that their expression weakened after treatment. Studies have investigated the possibility of a link between cancer stem cells and retinoid receptors. This link is likely to be useful in both the diagnosis and treatment of the disease.
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Keywords
retinoid receptors
retinoic acid
cancer stem cells Панкреатический рак
рецепторы ретиноидов
ретиноевая кислота
раковые стволовые клетки Mədəaltı vəzi xərçəngi
retinoid reseptorları
retinoy turşususu
xərçəng kök hüceyrələri