Spontaneous hypochromic anemia like as experimental model of antenatal therapy of cns disturbances by nootropile in rat pups

Abstract

Purpose of the study. To study the effect of Nootropil on the central nervous system of a fetus with hypoxia from pregnant rats with hypochromic anemia.
Materials and methods. Examngined 34 white mongrel rats of a female weighing 140-210 g and 116 rat pups obtained from them.4 series of experiments were delivered:control pregnant rats; pregnant rats in whom the method of hypochromic anemia was obtained by chronic bloodletting; pregnant rats with spontaneous hypochromic annemia , pregnant rats with spontaneous hypochromic annemia who received Nootropil on the 5th day of pregnancy before childbirth.
Results. The degree of disturbance of the central nervous system and the result of its correction with nootropile were determined by the body weight of the animals, holding tests on a horizontal rope and turning them on a olane, etc. The results of our experiments showed that antenatal therapy with nootropile is very useful and in most cases it eliminates disorders of the central nervous system.
Conclusions. Thus, the study of the effects of drugs in pharmacological experiments and trials with hypochromic anemia can be more informative and accurate when studying the blood parameters of rats with spontaneous anemia. Thus, treatment with nootropic drugs during pregnancy is a good result in preventing central nervous system disorders in the newborn.