RESULTS OF THE STUDY OF SYNCYTIAL CONNECTIONS BETWEEN NEUROCIES OF GANGLİONS OF LARGE İNTESTİNE
Abstract
The aim of the study was to determine the presence of syncytial connections between the neurons of the ganglia. The study material included various sections of the colon taken from 61 corpses of both sexes at different ages of extrauterine human development, 64 pieces of resection and biopsy material obtained as a result of surgical interventions on this organ. The pieces were cut from the proximal, middle and distal thirds of the colon. The obtained material was fixed in 10% neutral formalin or Carnoy's fluid.
The fixed pieces were treated with alcohol 960, and then embedded in paraffin. From these pieces, sections 5-7 μm thick were made. The prepared preparations were stained with hematoxylin and eosin, methylene blue, Van Gieson's methods, silver salt impregnation (Ranvier-Goyer and Bielschowsky-Gross methods), and the universal method of selective argyrophilic structure detection impregnation.
We determined that connections between neurons can be formed in two ways. The first way - the connection is obtained as a result of joining the ends of fibers in the contact zone. The second way syncytial cytoplasmic connections are formed by matching the processes of neighboring nerve cells. Thick interneuronal bridges, called paired proximal syncytial junctions, are found throughout the colon. We observed the transformation of neurons located close to each other into a large binuclear cell. In some cases, 3 or more syncytial connections are observed in the neuronal membranes. The obtained data can be useful for pathophysiologists to optimize the pathogenesis of numerous pathologies of the gastrointestinal system, and for gastroenterologists to improve the quality of treatment of various nosological forms of this organ.
References
Mazzarello, P. Net without nodes and vice versa, the paradoxical Golgi-Kajal story: a reconciliation? // Brain Research Bulletin – 2007. Jan;71(4), – р. 344–346.
Kajal R. Neuron theory or reticular theory? Objective evidence of the anatomical unity of nerve cells / R.Kajal. – Madrid: Inst. «Ramon y Kajal», – 1954. – 144 s.
Rovenska, E, Rovensky, J. Structure and function of lymphatic capillaries in synovial joint // Journal of Czech Physicians. – 2012. 151(11), – p. 520-522.
Jabeen, S., Thirumalai, V. The interplay between electrical and chemical synaptogenesis // J Neurophysiology, – 2018. Oct;120(4), – p. 1914-1922.
Pereda, A. Electrical synapses and their functional interactions with chemical synapses // Nature Reviews Neuroscience. – 2014. Apr;15(4), – p. 250-263.
Şadlinski, V.B., Hüseynova. G.A. Periferik sinirlərin anatomiyası / V.B.Şadlinski, G.A.Hüseynova. – Bakı: Müəllim, – 2008. –177 s.
Абдуллаев, А.С. Холинергическая и норадренергическая иннервация губных желез крыс // ‒ Кутаиси: Кутаисский медицинский журнал, ‒ 1998. №1, ‒ с.10-11
Сотников, О.С. Объединенная нейронно-ретикулярная теория / О.С.Сотников, // – Санкт-Петербург: Наука, – 2019. – 239 с.
Коржевский, Д.Э. Основы гистологической техники / Д.Э.Коржевский – Санкт-Петербург: Спец.Лит, – 2010. – 95 c.
Даценко, А.В., Казьмин, В.И. Импрегнация микроглиоцитов солью серебра на гистологических срезах гиппокампа кроликов // – Саратов: Саратовский научно-медицинский журнал. – 2016. №4, – с. 692-695
Марков, И.И. Универсальный метод элективного выявления аргирофильных структур / И.И.Марков, Е.С.Петров,В.И.Маркова // Морфологические ведомости. – Самара: – 2016. № 1. – с. 114 – 117
Сотников, О.С. Экспериментальное моделирование и обсуждение синцитиальных связей в нервной системе / О.С.Сотников, Х.М.Парамонова , А.А.Лактиононва [и др.] // – Санкт-Петербург: Морфология, –
№6, – с.15-20
Gershon, M., Margolis, K. The gut, its microbiome, and the brain: connections and communications // Journal of Clinical Investigation. – 2021. Sep;131(18), – p. e143768.
Archakova, L. Syncytial cytoplasmic anastomoses between neurites in caudal mesenteric qanqlion cells in adult cats / L.Archakova, O.Sotnikov, S.Novakovskaya [et al.] // Neuroscience and Behavioral Physiology, – 2010. 40(4), – р. 447 – 450.
Keywords
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.