Prognostic value of the angiogenesis receptor (cd-31) in the serous and mucinous ovarian cystadenocarcinomas

Abstract

The purpose of the study. Study of the relationship between angiogenesis and prognosis in serous and mucinous ovarian cystadenocarcinomas.

Material and  methods. Taking into account the specifics of the study, we used a complex of light-optical and histochemical methods of material analysis. For immunohistochemical investigation, the material which was frozen in liquid nitrogen, from which cryostat sections were made, followed by fixation in acetone, as well as material of paraffin blocks fixed in 10% formalin. The corresponding sections (7.0–10.0 µm) were processed with a standard set of avidin-biotin reaction using mouse monoclonal antibodies to angiogenesis receptor (DM-31) (DAKO, France).

Results of research. A total of 96 patients with a diagnosis of serous and mucinous ovarian cystadenocarcinoma were summarized and analyzed. The pronounced activity of stromal elements in serous cystadenocarcinoma was 27.8 ± 6.1% of cases; in mucinous cystadenocarcinoma, pronounced activity occurred in more than half of the cases. On the contrary, low activity of the angiogenesis receptor (DM-31) prevails in serous ovarian cystadenocarcinomas (p <0.05)